Seresto Flea and Tick Collar for Dogs and Cats (Imidacloprid/Flumethrin, EPA Safety Review, 8-Month Sustained Release) — pet safety profile
Moderate riskSeresto collars combine the neonicotinoid imidacloprid (10%) with the pyrethroid flumethrin (4.5%) in a polymer matrix that provides 8-month sustained release for flea and tick prevention on dogs and cats.
What is this product?
Seresto collars combine the neonicotinoid imidacloprid (10%) with the pyrethroid flumethrin (4.5%) in a polymer matrix that provides 8-month sustained release for flea and tick prevention on dogs and cats. Seresto became the best-selling flea/tick collar worldwide with over 25 million units sold annually, but faced scrutiny after a 2021 USA Today investigation reported over 2,500 pet deaths and 75,000+ adverse incident reports linked to the product in the EPA Incident Data System. EPA conducted an enhanced review (2021-2023) and concluded the overall safety profile was acceptable given the large user population, though neurological adverse events (ataxia, tremors) occurred at rates above background. Imidacloprid acts on nicotinic acetylcholine receptors in arthropods; flumethrin is a Type II pyrethroid affecting sodium channels.
What's in it
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Active Ingredient
Synergist Class
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