Permethrin Spot-On Flea and Tick Treatment for Dogs (Pyrethroid Topical, Cat-Lethal, Neurotoxic to Aquatic Invertebrates) — pet safety profile
High riskPermethrin spot-on treatments are the most widely used topical flea and tick products for dogs, applied monthly as a liquid between the shoulder blades.
What is this product?
Permethrin spot-on treatments are the most widely used topical flea and tick products for dogs, applied monthly as a liquid between the shoulder blades. Permethrin is a synthetic pyrethroid that disrupts sodium channel function in arthropod nervous systems, providing 30-day kill and repellency against fleas, ticks, and mosquitoes. Critically, permethrin is extremely toxic to cats — feline UDP-glucuronosyltransferase deficiency prevents metabolism, causing tremors, seizures, and death at doses tolerated by dogs. ASPCA Animal Poison Control Center reports permethrin is the #1 cause of feline pesticide poisoning, with multi-cat/dog households at highest risk from cross-contact. Aquatic toxicity is severe: LC50 for Daphnia magna is 0.6 micrograms per liter.
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