Pet Safety / Compounds / Toltrazuril

Is Toltrazuril safe for dogs and cats?

Low risk for pets

Used off-label for canine coccidiosis. Single-dose treatment. Well-tolerated.

What is toltrazuril?

CAS number
69004-03-1
Molecular formula
C18H14F3NO4S
Molecular weight
425.37 g/mol
SMILES
CC1=CC(=CC=C1OC2=CC(=CC(=C2)N3C(=O)SC(=O)N3)C(F)(F)F)OC
PubChem CID
71726

Risk for dogs

Low risk

Used off-label for canine coccidiosis. Single-dose treatment. Well-tolerated.

Risk for cats

Low risk

Used for feline coccidiosis. Single-dose. Safe at label doses.

Regulatory consensus

1 regulatory bodyhas classified Toltrazuril.

AgencyYearClassificationNotes
EU2010Authorized veterinary medicinal product; MRLs established

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter toltrazuril

  • Veterinary Medicine

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Toltrazuril:

  • Amprolium (prophylaxis)
    Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
    Relative cost: 1.2-2×
  • Diclazuril
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×

Frequently asked questions

Is toltrazuril safe for pets?

Used off-label for canine coccidiosis. Single-dose treatment. Well-tolerated.

See Toltrazuril in the pets app

Look up products containing toltrazuril, compare to alternatives, and explore the full data record.

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Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →