Pet Safety / Compounds / Sarolaner

Is Sarolaner safe for dogs and cats?

Low risk for pets

FDA-approved. Rare neurologic events in susceptible dogs.

What is sarolaner?

CAS number
1398609-91-2
Molecular formula
C24H22Cl2F5N3O5S2
Molecular weight
648.48 g/mol
SMILES
CC1(CC1C(=O)NC2=CC(=CC(=C2Cl)OC(F)F)S(=O)(=O)C3=CC(=NN3)C(F)(F)F)CS(=O)(=O)C
PubChem CID
71455818

Risk for dogs

Low risk

FDA-approved. Rare neurologic events in susceptible dogs.

Risk for cats

Low risk

Part of Revolution Plus — approved for cats.

Regulatory consensus

1 regulatory bodyhas classified Sarolaner.

AgencyYearClassificationNotes
FDA2016Approved veterinary drug (NADA 141-468)

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter sarolaner

  • Veterinary Medicine

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Sarolaner:

  • Fluralaner (Bravecto)
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×
  • Afoxolaner (NexGard)
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×

Frequently asked questions

Is sarolaner safe for pets?

FDA-approved. Rare neurologic events in susceptible dogs.

See Sarolaner in the pets app

Look up products containing sarolaner, compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →