Pet Safety / Compounds / Sarolaner

Is Sarolaner safe for dogs and cats?

Low risk for pets

Not veterinary or professional safety advice, and not a substitute for a veterinarian — consult one about your animal. Full disclaimer →

FDA-approved. Rare neurologic events in susceptible dogs.

What is sarolaner?

The IUPAC name is 1-[6-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone.

Also known as: 1398609-39-6, Simparica, PF-6450567, DM113FTW7F.

IUPAC name
1-[6-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone
CAS number
1398609-39-6
Molecular formula
C24H22Cl2F5N3O5S2
Molecular weight
648.48 g/mol
SMILES
CS(=O)(=O)CC(=O)N1CC2(C1)C3=C(CO2)C=C(C=C3)C4=NO[C@@](C4)(C5=CC(=C(C(=C5)Cl)F)Cl)C(F)(F)F
PubChem CID
73169092

Risk for dogs

Low risk

FDA-approved. Rare neurologic events in susceptible dogs.

Risk for cats

Low risk

Part of Revolution Plus — approved for cats.

Regulatory consensus

1 regulatory body has classified Sarolaner.

AgencyYearClassificationNotes
FDA2016Approved veterinary drug (NADA 141-468)

Where pets encounter sarolaner

  • Veterinary Medicine

Frequently asked questions

Is sarolaner safe for pets?

FDA-approved. Rare neurologic events in susceptible dogs.

See Sarolaner in the pets app

Look up products containing sarolaner, compare to alternatives, and explore the full data record.

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Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →