Pet Safety / Compounds / Robenacoxib

Is Robenacoxib safe for dogs and cats?

Low risk for pets

Not veterinary or professional safety advice, and not a substitute for a veterinarian — consult one about your animal. Full disclaimer →

FDA-approved. Tissue-selective pharmacokinetics.

What is robenacoxib?

The IUPAC name is 2-[5-ethyl-2-(2,3,5,6-tetrafluoroanilino)phenyl]acetic acid.

Also known as: 220991-32-2, Onsior, 2-(5-Ethyl-2-((2,3,5,6-tetrafluorophenyl)amino)phenyl)acetic acid, robenacoxibum.

IUPAC name
2-[5-ethyl-2-(2,3,5,6-tetrafluoroanilino)phenyl]acetic acid
CAS number
220991-32-2
Molecular formula
C21H18F3NO3
Molecular weight
377.37 g/mol
SMILES
CCC1=CC(=C(C=C1)NC2=C(C(=CC(=C2F)F)F)F)CC(=O)O
PubChem CID
6433107

Risk for dogs

Low risk

FDA-approved. Tissue-selective pharmacokinetics.

Risk for cats

Moderate risk

FDA-approved for cats — first NSAID for repeated use in cats. Much wider safety margin than others.

Regulatory consensus

1 regulatory bodyhas classified Robenacoxib.

AgencyYearClassificationNotes
FDA2011Approved veterinary drug (NADA 141-320, 141-463)

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter robenacoxib

  • Veterinary Medicine

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Robenacoxib:

  • Meloxicam (single injection, cats)
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×
  • Grapiprant (dogs)
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×

Frequently asked questions

Is robenacoxib safe for pets?

FDA-approved. Tissue-selective pharmacokinetics.

See Robenacoxib in the pets app

Look up products containing robenacoxib, compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →