Pet Safety / Compounds / R-1234ze(E) (trans-1,3,3,3-Tetrafluoropropene)

Is R-1234ze(E) (trans-1,3,3,3-Tetrafluoropropene) safe for dogs and cats?

Low risk for pets

Low toxicity concern.

What is r-1234ze(e) (trans-1,3,3,3-tetrafluoropropene)?

Also known as: Ethiocholanolone, TMS, 3A-Hydroxy-5B-androstan-17-one, bis-TMS.

CAS number
29118-25-0
Molecular formula
C3H2F4
Molecular weight
114.04 g/mol
SMILES
CC12CCC(CC1CCC3C2CCC4(C3CCC4O[Si](C)(C)C)C)O[Si](C)(C)C
PubChem CID
6431230

Risk for dogs

Low risk

Low toxicity concern.

Risk for cats

Low risk

Low toxicity concern.

Regulatory consensus

4 regulatory and scientific bodies have classified R-1234ze(E) (trans-1,3,3,3-Tetrafluoropropene). The classifications differ — that's the data.

AgencyYearClassificationNotes
EU F GAS—Exempt from phase-down (GWP<150). Preferred replacement in commercial refrigeration
EPA SNAP—Listed as acceptable substitute in multiple end uses
ASHRAE 34—A2L safety classification
REACH—Registered under EU REACH

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter r-1234ze(e) (trans-1,3,3,3-tetrafluoropropene)

  • Commercial Chillers — Centrifugal and screw chillers for large buildings and data centers
  • Heat Pumps — High-temperature heat pumps for industrial and district heating
  • Foam Blowing — Replacement for HFC-134a and HFC-152a in spray foam insulation
  • Aerosol Propellant — Medical inhalers and consumer aerosols replacing HFC-134a
  • Vending Machines — Self-contained commercial refrigeration

Safer alternatives

Lower-risk approaches that achieve a similar outcome to R-1234ze(E) (trans-1,3,3,3-Tetrafluoropropene):

  • R-744 (CO2)
    Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
    Relative cost: 1.2-2×
  • R-717 (Ammonia)
    Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
    Relative cost: 1.2-2×

Frequently asked questions

Is r-1234ze(e) (trans-1,3,3,3-tetrafluoropropene) safe for pets?

Low toxicity concern.

What products contain r-1234ze(e) (trans-1,3,3,3-tetrafluoropropene)?

R-1234ze(E) (trans-1,3,3,3-Tetrafluoropropene) appears in: Centrifugal and screw chillers for large buildings and data centers (Commercial Chillers); High-temperature heat pumps for industrial and district heating (Heat Pumps); Replacement for HFC-134a and HFC-152a in spray foam insulation (Foam Blowing).

Why do regulators disagree about r-1234ze(e) (trans-1,3,3,3-tetrafluoropropene)?

R-1234ze(E) (trans-1,3,3,3-Tetrafluoropropene) has been classified by 4 agencies including EU F GAS, EPA SNAP, ASHRAE 34, REACH, with differing conclusions. Regulators apply different standards of evidence (animal data weighting, exposure-pattern assumptions, epidemiological power thresholds), which is why two scientific bodies can review the same data and reach different conclusions. See the regulatory consensus table on this page for the full picture.

See R-1234ze(E) (trans-1,3,3,3-Tetrafluoropropene) in the pets app

Look up products containing r-1234ze(e) (trans-1,3,3,3-tetrafluoropropene), compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (1)
  1. — expert_curation

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →