Pet Safety / Compounds / Propiconazole

Is Propiconazole safe for dogs and cats?

Low risk for pets

Low acute toxicity to dogs. Treated wood chewing may cause mild GI effects.

What is propiconazole?

The IUPAC name is 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole.

Also known as: 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole, Desmel, Banner, Orbit.

IUPAC name
1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole
CAS number
60207-90-1
Molecular formula
C15H17Cl2N3O2
Molecular weight
342.2 g/mol
SMILES
CCCC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl
PubChem CID
43234

Risk for dogs

Low risk

Low acute toxicity to dogs. Treated wood chewing may cause mild GI effects.

Risk for cats

Low risk

Low concern.

Regulatory consensus

12 regulatory and scientific bodies have classified Propiconazole. The classifications differ — that's the data.

AgencyYearClassificationNotes
EPA CTX / EPA OPP—Group C Possible Human Carcinogen
EPA CTX / Skin-Eye—Skin Sensitization: Skin Sens. 1 (score: high)
EPA CTX / Skin-Eye—Eye Irritation: Category 2B (score: moderate)
EPA CTX / Skin-Eye—Skin Irritation: Not classified (score: low)
EPA CTX / Skin-Eye—Skin Sensitization: Category 1 (score: high)
EPA CTX / Skin-Eye—Eye Irritation: Category 6.4A (Category 2A) (score: high)
EPA CTX / Skin-Eye—Skin Irritation: Category 6.3B (Category 3) (score: moderate)
US_EPA2024registeredEPA-registered fungicide.
EU_REACH2019non_renewalEU non-renewal (reproductive toxicity).
EFSA—ADI 0.04 mg/kg bw/day. ARfD 0.1 mg/kg bw. Part of cumulative triazole assessment
EU BPR—Candidate for substitution under BPR due to endocrine disruption concerns. Approved until 2025 with conditions
EPA—Registered fungicide/wood preservative under FIFRA. Group C possible human carcinogen

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter propiconazole

  • Industrial Facilities — Manufacturing plants, Chemical storage areas, Waste treatment sites
  • Occupational Environments — Factories, Warehouses, Transportation vehicles
  • Wood Preservation — Pressure-treated lumber (copper azole formulations), Millwork and joinery treatment, Composite decking preservative
  • Agriculture — Cereal crop fungicide (wheat, barley, rice), Turf/golf course fungicide (Banner MAXX), Tree fruit and nut orchards
  • Paint And Coatings — In-can paint preservative (anti-fungal), Exterior wood stain fungicide component
  • Consumer Products — Deck stains and sealers with mildewcide, Composite lumber preservative system

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Propiconazole:

  • Physical/mechanical pest control (IPM)
    Trade-offs: More labor-intensive. May not be sufficient for severe infestations.
    Relative cost: 1.2-2×
  • Copper-based fungicides
    Relative cost: 1.2-2×
  • Bacillus subtilis
    Relative cost: 1.2-2×
  • Trichoderma biological control
    Relative cost: 1.2-2×
  • Tebuconazole
    Relative cost: 1.2-2×
  • DCOIT (Sea-Nine)
    Relative cost: 1.2-2×

Frequently asked questions

Is propiconazole safe for pets?

Low acute toxicity to dogs. Treated wood chewing may cause mild GI effects.

What products contain propiconazole?

Propiconazole appears in: Manufacturing plants (Industrial facilities); Chemical storage areas (Industrial facilities); Factories (Occupational environments); Warehouses (Occupational environments); Pressure-treated lumber (copper azole formulations) (Wood preservation).

Why do regulators disagree about propiconazole?

Propiconazole has been classified by 12 agencies including EPA CTX / EPA OPP, EPA CTX / Skin-Eye, EPA CTX / Skin-Eye, EPA CTX / Skin-Eye, EPA CTX / Skin-Eye, with differing conclusions. Regulators apply different standards of evidence (animal data weighting, exposure-pattern assumptions, epidemiological power thresholds), which is why two scientific bodies can review the same data and reach different conclusions. See the regulatory consensus table on this page for the full picture.

See Propiconazole in the pets app

Look up products containing propiconazole, compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (1)
  1. US EPA: Propiconazole Registration Review — Likely Carcinogen Classification (CAR/PXR Mechanism), Dietary Risk Assessment, and Occupational Exposure (2006–2018) (2018) — regulatory

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →