Pet Safety / Compounds / Perfluoroisobutylene (PFIB)

Is Perfluoroisobutylene (PFIB) safe for dogs and cats?

High risk for pets

Perfluoroisobutylene (PFIB) is acutely toxic (GHS Category 1-3). Dogs may access through household exposure. Contact veterinarian immediately if exposure suspected.

What is perfluoroisobutylene (pfib)?

The IUPAC name is 1,1,3,3,3-pentafluoro-2-(trifluoromethyl)prop-1-ene.

Also known as: 1,1,3,3,3-pentafluoro-2-(trifluoromethyl)prop-1-ene, Perfluoroisobutylene, Octafluoroisobutylene, PFIB.

IUPAC name
1,1,3,3,3-pentafluoro-2-(trifluoromethyl)prop-1-ene
CAS number
382-21-8
Molecular formula
C4F8
Molecular weight
200.03 g/mol
SMILES
C(=C(F)F)(C(F)(F)F)C(F)(F)F
PubChem CID
61109

Risk for dogs

High risk

Perfluoroisobutylene (PFIB) is acutely toxic (GHS Category 1-3). Dogs may access through household exposure. Contact veterinarian immediately if exposure suspected.

Risk for cats

High risk

Perfluoroisobutylene (PFIB) is acutely toxic (GHS Category 1-3). Cats are particularly vulnerable due to grooming behavior and glucuronidation deficiency.

Regulatory consensus

1 regulatory bodyhas classified Perfluoroisobutylene (PFIB).

AgencyYearClassificationNotes
Unknown——

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter perfluoroisobutylene (pfib)

  • Industrial Facilities — Manufacturing plants, Chemical storage areas, Waste treatment sites
  • Occupational Environments — Factories, Warehouses, Transportation vehicles

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Perfluoroisobutylene (PFIB):

  • Exposure reduction (environmental contaminant)
    Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
    Relative cost: 1.2-2×

Frequently asked questions

Is perfluoroisobutylene (pfib) safe for pets?

Perfluoroisobutylene (PFIB) is acutely toxic (GHS Category 1-3). Dogs may access through household exposure. Contact veterinarian immediately if exposure suspected.

What products contain perfluoroisobutylene (pfib)?

Perfluoroisobutylene (PFIB) appears in: Manufacturing plants (Industrial facilities); Chemical storage areas (Industrial facilities); Factories (Occupational environments); Warehouses (Occupational environments).

See Perfluoroisobutylene (PFIB) in the pets app

Look up products containing perfluoroisobutylene (pfib), compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (4)
  1. OSHA: Perfluoroisobutylene (PFIB) Safety Data (2010) — regulatory
  2. Acute pulmonary edema following PTFE fume exposure in humans (1990) — journal
  3. Pet bird mortality from PTFE pyrolysis products — toxicology and prevention (2005) — journal
  4. NIOSH: Polymer Fume Fever and PTFE Decomposition Hazards (2008) — government

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →