Pet Safety / Compounds / Nano-hydroxyapatite (n-HAp)

Is Nano-hydroxyapatite (n-HAp) safe for dogs and cats?

Low risk for pets

Used in some veterinary dental products. Biocompatible.

What is nano-hydroxyapatite (n-hap)?

The IUPAC name is pentacalcium;hydroxide;triphosphate.

Also known as: Durapatite, 1306-06-5, Calcium hydroxyapatite, Radiesse.

IUPAC name
pentacalcium;hydroxide;triphosphate
CAS number
1306-06-5
Molecular formula
Ca5HO13P3
Molecular weight
502.3 g/mol
SMILES
[OH-].[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2]
PubChem CID
14781

Risk for dogs

Low risk

Used in some veterinary dental products. Biocompatible.

Risk for cats

Low risk

Minimal exposure. Biocompatible if ingested.

Regulatory consensus

3 regulatory and scientific bodies have classified Nano-hydroxyapatite (n-HAp). The classifications differ — that's the data.

AgencyYearClassificationNotes
EU SCCS2023Safe in oral cosmetics (non-nano or rod-shaped nano ≤10%); needle-shaped nano form potentially genotoxic — not safe
Japan1980Approved dental ingredient since 1980s (Sangi/Apagard)
Canada2024Under Health Canada assessment for cosmetic use

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter nano-hydroxyapatite (n-hap)

  • Personal Care
  • Medical Device

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Nano-hydroxyapatite (n-HAp):

  • Fluoride (sodium fluoride, stannous fluoride)
    Trade-offs: Well-established efficacy but fluorosis risk at high intake. Nano-HAp may be preferred in fluoride-restricted markets (Japan).
    Relative cost: 0.1× nano-HAp
  • Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP)
    Trade-offs: Milk protein derivative — not suitable for dairy-allergic patients. Prescription product in some markets.
    Relative cost: 2× fluoride toothpaste

Frequently asked questions

Is nano-hydroxyapatite (n-hap) safe for pets?

Used in some veterinary dental products. Biocompatible.

Why do regulators disagree about nano-hydroxyapatite (n-hap)?

Nano-hydroxyapatite (n-HAp) has been classified by 3 agencies including EU SCCS, Japan, Canada, with differing conclusions. Regulators apply different standards of evidence (animal data weighting, exposure-pattern assumptions, epidemiological power thresholds), which is why two scientific bodies can review the same data and reach different conclusions. See the regulatory consensus table on this page for the full picture.

See Nano-hydroxyapatite (n-HAp) in the pets app

Look up products containing nano-hydroxyapatite (n-hap), compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →