Pet Safety / Compounds / N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid)

Is N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid) safe for dogs and cats?

Moderate risk for pets

Dogs exposed via food and water contamination. Transforms to PFOS.

What is n-mefosaa (n-methyl perfluorooctane sulfonamido acetic acid)?

The IUPAC name is 2-[1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctylsulfonyl(methyl)amino]acetic acid.

Also known as: 2355-31-9, NMeFOSAA, 2-(N-Methylperfluorooctanesulfonamido)acetic acid, N-MeFOSAA.

IUPAC name
2-[1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctylsulfonyl(methyl)amino]acetic acid
CAS number
2355-31-9
Molecular formula
C11H6F17NO4S
Molecular weight
571.21 g/mol
SMILES
CN(CC(=O)O)S(=O)(=O)C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F
PubChem CID
22286931

Risk for dogs

Moderate risk

Dogs exposed via food and water contamination. Transforms to PFOS.

Risk for cats

Moderate risk

Indoor exposure via dust from treated furnishings. Transforms to PFOS.

Regulatory consensus

2 regulatory and scientific bodies have classified N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid). The classifications differ — that's the data.

AgencyYearClassificationNotes
EPA——
CDC/ATSDR——

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter n-mefosaa (n-methyl perfluorooctane sulfonamido acetic acid)

  • Human Biomonitoring — NHANES blood samples, General population serum
    One of 7 PFAS routinely detected in >95% of NHANES participants
  • Food Packaging — Historical 3M grease-proofing treatments, Legacy food-contact paper coatings
    Metabolite of N-MeFOSE-based paper treatments

Safer alternatives

Lower-risk approaches that achieve a similar outcome to N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid):

  • Non-fluorinated food packaging (wax, clay, silicone coatings)
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×

Frequently asked questions

Is n-mefosaa (n-methyl perfluorooctane sulfonamido acetic acid) safe for pets?

Dogs exposed via food and water contamination. Transforms to PFOS.

What products contain n-mefosaa (n-methyl perfluorooctane sulfonamido acetic acid)?

N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid) appears in: NHANES blood samples (human biomonitoring); General population serum (human biomonitoring); Historical 3M grease-proofing treatments (food packaging); Legacy food-contact paper coatings (food packaging).

See N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid) in the pets app

Look up products containing n-mefosaa (n-methyl perfluorooctane sulfonamido acetic acid), compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (1)
  1. — expert_curation

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →