Pet Safety / Compounds / Mitragynine

Is Mitragynine safe for dogs and cats?

High risk for pets

Dogs may access kratom capsules/powder. Opioid-like effects and hepatotoxicity reported in case series.

What is mitragynine?

The IUPAC name is methyl (E)-2-[(2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate.

Also known as: 4098-40-2, (-)-Mitragynine, 9-Methoxycorynantheidine, Skf 12711.

IUPAC name: methyl (E)-2-[(2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
CAS number: 4098-40-2
Molecular formula: C23H30N2O4
Molecular weight: 398.5 g/mol
SMILES: CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC
PubChem CID: 3034396

Risk for dogs

High risk

Dogs may access kratom capsules/powder. Opioid-like effects and hepatotoxicity reported in case series.

Risk for cats

High risk

No veterinary data. Opioid sensitivity in cats makes any exposure concerning.

Regulatory consensus

2 regulatory and scientific bodies have classified Mitragynine. The classifications differ — that's the data.

Agency	Year	Classification	Notes
FDA	2014	Import Alert 54-15 — unapproved new drug; not GRAS
DEA	2016	Drug and Chemical of Concern (not currently scheduled federally)

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter mitragynine

Natural Product
Supplement

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Mitragynine:

Buprenorphine/naloxone (Suboxone)
Trade-offs: Prescription required. Partial opioid agonist. Well-studied safety profile. Diversion risk.

Relative cost: $100-500/month

Frequently asked questions

Is mitragynine safe for pets?

Dogs may access kratom capsules/powder. Opioid-like effects and hepatotoxicity reported in case series.

See Mitragynine in the pets app

Look up products containing mitragynine, compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (1)

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →