Pet Safety / Compounds / Mescaline (3,4,5-trimethoxyphenethylamine)

Is Mescaline (3,4,5-trimethoxyphenethylamine) safe for dogs and cats?

Elevated risk for pets

Not veterinary or professional safety advice, and not a substitute for a veterinarian — consult one about your animal. Full disclaimer →

Peyote cactus ingestion causes vomiting, ataxia, tremors, mydriasis. Supportive care; generally self-limiting if small amount.

What is mescaline (3,4,5-trimethoxyphenethylamine)?

The IUPAC name is 2-(3,4,5-trimethoxyphenyl)ethanamine.

Also known as: mescaline, Mescalin, 3,4,5-Trimethoxyphenethylamine, Mezcaline.

IUPAC name
2-(3,4,5-trimethoxyphenyl)ethanamine
CAS number
54-04-6
Molecular formula
C11H17NO3
Molecular weight
211.26 g/mol
SMILES
COc1cc(CCN)cc(OC)c1OC
PubChem CID
4076

Risk for dogs

Elevated risk

Peyote cactus ingestion causes vomiting, ataxia, tremors, mydriasis. Supportive care; generally self-limiting if small amount.

Risk for cats

Elevated risk

Similar effects as dogs; more sensitive to CNS effects. San Pedro/peyote ingestion uncommon in cats.

Regulatory consensus

2 regulatory and scientific bodies have classified Mescaline (3,4,5-trimethoxyphenethylamine). The classifications differ — that's the data.

AgencyYearClassificationNotes
DEA1970Schedule I (except peyote for NAC religious use)
UN19711971 Convention — Schedule I (mescaline itself; peyote cactus not scheduled)

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter mescaline (3,4,5-trimethoxyphenethylamine)

  • Natural Product
  • Illicit Drug

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Mescaline (3,4,5-trimethoxyphenethylamine):

  • Psilocybin (in clinical setting)
    Trade-offs: Different pharmacology (5-HT2A agonist). Shorter duration (4-6h vs 8-12h). FDA Breakthrough Therapy designation.
    Relative cost: Clinical trial context only

Frequently asked questions

Is mescaline (3,4,5-trimethoxyphenethylamine) safe for pets?

Peyote cactus ingestion causes vomiting, ataxia, tremors, mydriasis. Supportive care; generally self-limiting if small amount.

Why do regulators disagree about mescaline (3,4,5-trimethoxyphenethylamine)?

Mescaline (3,4,5-trimethoxyphenethylamine) has been classified by 2 agencies including DEA, UN, with differing conclusions. Regulators apply different standards of evidence (animal data weighting, exposure-pattern assumptions, epidemiological power thresholds), which is why two scientific bodies can review the same data and reach different conclusions. See the regulatory consensus table on this page for the full picture.

See Mescaline (3,4,5-trimethoxyphenethylamine) in the pets app

Look up products containing mescaline (3,4,5-trimethoxyphenethylamine), compare to alternatives, and explore the full data record.

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Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →