Pet Safety / Compounds / Mescaline (3,4,5-trimethoxyphenethylamine)

Is Mescaline (3,4,5-trimethoxyphenethylamine) safe for dogs and cats?

Elevated risk for pets

Peyote cactus ingestion causes vomiting, ataxia, tremors, mydriasis. Supportive care; generally self-limiting if small amount.

What is mescaline (3,4,5-trimethoxyphenethylamine)?

The IUPAC name is 2-(3,4,5-trimethoxyphenyl)ethanamine.

Also known as: mescaline, Mescalin, 3,4,5-Trimethoxyphenethylamine, Mezcaline.

IUPAC name
2-(3,4,5-trimethoxyphenyl)ethanamine
CAS number
54-04-6
Molecular formula
C11H17NO3
Molecular weight
211.26 g/mol
SMILES
COc1cc(CCN)cc(OC)c1OC
PubChem CID
4076

Risk for dogs

Elevated risk

Peyote cactus ingestion causes vomiting, ataxia, tremors, mydriasis. Supportive care; generally self-limiting if small amount.

Risk for cats

Elevated risk

Similar effects as dogs; more sensitive to CNS effects. San Pedro/peyote ingestion uncommon in cats.

Regulatory consensus

2 regulatory and scientific bodies have classified Mescaline (3,4,5-trimethoxyphenethylamine). The classifications differ — that's the data.

AgencyYearClassificationNotes
DEA1970Schedule I (except peyote for NAC religious use)
UN19711971 Convention — Schedule I (mescaline itself; peyote cactus not scheduled)

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter mescaline (3,4,5-trimethoxyphenethylamine)

  • Natural Product
  • Illicit Drug

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Mescaline (3,4,5-trimethoxyphenethylamine):

  • Psilocybin (in clinical setting)
    Trade-offs: Different pharmacology (5-HT2A agonist). Shorter duration (4-6h vs 8-12h). FDA Breakthrough Therapy designation.
    Relative cost: Clinical trial context only

Frequently asked questions

Is mescaline (3,4,5-trimethoxyphenethylamine) safe for pets?

Peyote cactus ingestion causes vomiting, ataxia, tremors, mydriasis. Supportive care; generally self-limiting if small amount.

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Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →