Pet Safety / Compounds / Maropitant

Is Maropitant safe for dogs and cats?

Low risk for pets

Not veterinary or professional safety advice, and not a substitute for a veterinarian — consult one about your animal. Full disclaimer →

FDA-approved antiemetic. Also provides visceral pain relief.

What is maropitant?

The IUPAC name is (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine.

Also known as: 147116-67-4, 4XE2T9H4DH, 1-Azabicyclo[2.2.2]octan-3-amine, N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-, (2S,3S)-, DTXSID1057874.

IUPAC name
(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine
CAS number
147116-67-4
Molecular formula
C32H40N2O
Molecular weight
468.7 g/mol
SMILES
CC(C)(C)C1=CC(=C(C=C1)OC)CN[C@@H]2[C@@H](N3CCC2CC3)C(C4=CC=CC=C4)C5=CC=CC=C5
PubChem CID
204108

Risk for dogs

Low risk

FDA-approved antiemetic. Also provides visceral pain relief.

Risk for cats

Low risk

FDA-approved for cats. Motion sickness and vomiting.

Regulatory consensus

1 regulatory body has classified Maropitant.

AgencyYearClassificationNotes
FDA2007Approved veterinary drug (NADA 141-291)

Where pets encounter maropitant

  • Veterinary Medicine

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Maropitant:

  • Ondansetron (off-label)
    Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
    Relative cost: 1.2-2×

Frequently asked questions

Is maropitant safe for pets?

FDA-approved antiemetic. Also provides visceral pain relief.

See Maropitant in the pets app

Look up products containing maropitant, compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (1)
  1. —

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →