Pet Safety / Compounds / Maropitant

Is Maropitant safe for dogs and cats?

Low risk for pets

FDA-approved antiemetic. Also provides visceral pain relief.

What is maropitant?

CAS number
147116-67-4
Molecular formula
C32H38F3N3O
Molecular weight
541.66 g/mol
SMILES
CC1CCC(CC(=O)NC2CC(C(N2)C3=CC=CC=C3)C4=CC=CC=C4)C(C1)NCC5=CC(=CC=C5)C(F)(F)F
PubChem CID
6450756

Risk for dogs

Low risk

FDA-approved antiemetic. Also provides visceral pain relief.

Risk for cats

Low risk

FDA-approved for cats. Motion sickness and vomiting.

Regulatory consensus

1 regulatory bodyhas classified Maropitant.

AgencyYearClassificationNotes
FDA2007Approved veterinary drug (NADA 141-291)

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter maropitant

  • Veterinary Medicine

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Maropitant:

  • Ondansetron (off-label)
    Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
    Relative cost: 1.2-2×
  • Metoclopramide
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×

Frequently asked questions

Is maropitant safe for pets?

FDA-approved antiemetic. Also provides visceral pain relief.

See Maropitant in the pets app

Look up products containing maropitant, compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →