Pet Safety / Compounds / Flupyradifurone

Is Flupyradifurone safe for dogs and cats?

Low risk for pets

Not used in veterinary products; environmental exposure from treated ornamentals, fruit, and vegetable crops. Very low acute mammalian toxicity; no specific dog health concerns at typical environmental exposures.

What is flupyradifurone?

The IUPAC name is 3-[(6-chloro-3-pyridinyl)methyl-(2,2-difluoroethyl)amino]-2H-furan-5-one.

Also known as: 3-[(6-chloro-3-pyridinyl)methyl-(2,2-difluoroethyl)amino]-2H-furan-5-one, 4-(((6-chloropyridin-3-yl)methyl)(2,2-difluoroethyl)amino)furan-2(5H)-one, 8H7JT159D0, BYI-02960.

IUPAC name
3-[(6-chloro-3-pyridinyl)methyl-(2,2-difluoroethyl)amino]-2H-furan-5-one
CAS number
951659-40-8
Molecular formula
C12H11ClF2N2O2
Molecular weight
288.68 g/mol
SMILES
C1C(=CC(=O)O1)N(CC2=CN=C(C=C2)Cl)CC(F)F
PubChem CID
16752772

Risk for dogs

Low risk

Not used in veterinary products; environmental exposure from treated ornamentals, fruit, and vegetable crops. Very low acute mammalian toxicity; no specific dog health concerns at typical environmental exposures.

Risk for cats

Low risk

Same low mammalian toxicity as for dogs; no cat-specific sensitivity. Environmental exposure from treated ornamental plants and garden crops is the primary cat contact scenario.

Regulatory consensus

1 regulatory bodyhas classified Flupyradifurone.

AgencyYearClassificationNotes
US EPA2015Toxicity Category IVEPA registration with specific restrictions to protect pollinators

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter flupyradifurone

  • Industrial Facilities — Manufacturing plants, Chemical storage areas, Waste treatment sites
  • Occupational Environments — Factories, Warehouses, Transportation vehicles

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Flupyradifurone:

  • Physical/mechanical pest control (IPM)
    Trade-offs: More labor-intensive. May not be sufficient for severe infestations.
    Relative cost: 1.2-2×

Frequently asked questions

Is flupyradifurone safe for pets?

Not used in veterinary products; environmental exposure from treated ornamentals, fruit, and vegetable crops. Very low acute mammalian toxicity; no specific dog health concerns at typical environmental exposures.

What products contain flupyradifurone?

Flupyradifurone appears in: Manufacturing plants (Industrial facilities); Chemical storage areas (Industrial facilities); Factories (Occupational environments); Warehouses (Occupational environments).

See Flupyradifurone in the pets app

Look up products containing flupyradifurone, compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (2)
  1. EFSA: Flupyradifurone Peer Review — bee risk assessment; synergism with EBI fungicides; acute and sublethal bee toxicity; comparison with neonicotinoid outdoor ban criteria; review of 'bee-safe' claims; EFSA Scientific Opinion (2020) (2020) — regulatory
  2. US EPA: Neonicotinoid Registration Review — imidacloprid, clothianidin, thiamethoxam, acetamiprid, dinotefuran; bee risk assessment; sublethal effects; colony-level modeling; pollinator exposure through pollen and nectar; aquatic invertebrate toxicity; registration review decision (2020) (2020) — regulatory

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →