Pet Safety / Compounds / diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2)

Is diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) safe for dogs and cats?

Moderate risk for pets

Not veterinary or professional safety advice, and not a substitute for a veterinarian — consult one about your animal. Full disclaimer →

Limited exposure from pet food packaging.

What is dipap (polyfluoroalkyl phosphate diester, 6:2/6:2)?

The IUPAC name is bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrogen phosphate.

Also known as: Bis[2-(perfluorohexyl)ethyl] Phosphate, bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrogen phosphate, Bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octanol) hydrogen phosphate, DTXSID50561590.

IUPAC name
bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrogen phosphate
CAS number
57677-95-9
Molecular formula
C16H9F26O4P
Molecular weight
790.17 g/mol
SMILES
C(COP(=O)(O)OCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F
PubChem CID
14550408

Risk for dogs

Moderate risk

Limited exposure from pet food packaging.

Risk for cats

Moderate risk

Limited exposure data.

Regulatory consensus

3 regulatory and scientific bodies have classified diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2). The classifications differ — that's the data.

AgencyYearClassificationNotes
FDA—Food contact notificationrevoked — FDA revoked authorization for certain PFAS in food packaging in 2024
ECHA—PFAS restriction proposalproposed restriction
Denmark—Food packaging banbanned — Denmark banned PFAS in food packaging in 2020

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter dipap (polyfluoroalkyl phosphate diester, 6:2/6:2)

  • Food Packaging — Fast food wrappers, Microwave popcorn bags, Pizza boxes, Bakery bags
    Dominant PFAS in food-contact paper — detected in >50% of fast food packaging
  • House Dust — Household dust, Office dust
    Dust from treated textiles and carpets contains diPAPs
  • Human Biomonitoring — General population serum, Fast food workers
    Detected in human blood — dietary exposure from food packaging is primary route

Safer alternatives

Lower-risk approaches that achieve a similar outcome to diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2):

  • Plant-based grease barriers
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×
  • Wax-coated paper
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×
  • Bamboo fiber packaging
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×
  • Silicone-coated paper
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×

Frequently asked questions

Is dipap (polyfluoroalkyl phosphate diester, 6:2/6:2) safe for pets?

Limited exposure from pet food packaging.

What products contain dipap (polyfluoroalkyl phosphate diester, 6:2/6:2)?

diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) appears in: Fast food wrappers (food packaging); Microwave popcorn bags (food packaging); Household dust (house dust); Office dust (house dust); General population serum (human biomonitoring).

Why do regulators disagree about dipap (polyfluoroalkyl phosphate diester, 6:2/6:2)?

diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) has been classified by 3 agencies including FDA, ECHA, Denmark, with differing conclusions. Regulators apply different standards of evidence (animal data weighting, exposure-pattern assumptions, epidemiological power thresholds), which is why two scientific bodies can review the same data and reach different conclusions. See the regulatory consensus table on this page for the full picture.

See diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) in the pets app

Look up products containing dipap (polyfluoroalkyl phosphate diester, 6:2/6:2), compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (1)
  1. — expert_curation

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →