Pet Safety / Compounds / Chlorophacinone

Is Chlorophacinone safe for dogs and cats?

High risk for pets

Chlorophacinone causes anticoagulant toxicosis in dogs via VKOR inhibition; clinical onset 2–5 days post-ingestion. Consumer bait formulations are accessible to dogs in agricultural and residential settings. Treatment: vitamin K1 for 2–4 weeks; prognosis good with early treatment. Outdoor burrowing pest applications (prairie dog, vole) in agricultural areas create exposure risks for working dogs and farm dogs that may encounter bait stations or poisoned animals.

What is chlorophacinone?

The IUPAC name is 2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione.

Also known as: 2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione, Liphadione, Chlorphacinon, Redentin.

IUPAC name
2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione
CAS number
3691-35-8
Molecular formula
C23H15ClO3
Molecular weight
374.8 g/mol
SMILES
C1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)C(=O)C3C(=O)C4=CC=CC=C4C3=O
PubChem CID
19402

Risk for dogs

High risk

Chlorophacinone causes anticoagulant toxicosis in dogs via VKOR inhibition; clinical onset 2–5 days post-ingestion. Consumer bait formulations are accessible to dogs in agricultural and residential settings. Treatment: vitamin K1 for 2–4 weeks; prognosis good with early treatment. Outdoor burrowing pest applications (prairie dog, vole) in agricultural areas create exposure risks for working dogs and farm dogs that may encounter bait stations or poisoned animals.

Risk for cats

High risk

Chlorophacinone toxicosis in cats follows the same anticoagulant mechanism; farm cats in agricultural areas where chlorophacinone is used for vole or ground squirrel control are at risk through prey consumption. Hemorrhagic signs with 2–5 day onset. Vitamin K1 for 2–4 weeks.

Regulatory consensus

1 regulatory bodyhas classified Chlorophacinone.

AgencyYearClassificationNotes
Unknown——

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter chlorophacinone

  • Industrial Facilities — Manufacturing plants, Chemical storage areas, Waste treatment sites
  • Occupational Environments — Factories, Warehouses, Transportation vehicles

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Chlorophacinone:

  • Integrated Pest Management (IPM); Biopesticides; Physical controls
    Trade-offs: Combines biological, cultural, and targeted chemical controls; reduces overall chemical use 30-70%; requires trained practitioners and monitoring infrastructure; higher management complexity; proven effective at scale in many crop systems.
    Relative cost: 1.2-2×

Frequently asked questions

Is chlorophacinone safe for pets?

Chlorophacinone causes anticoagulant toxicosis in dogs via VKOR inhibition; clinical onset 2–5 days post-ingestion. Consumer bait formulations are accessible to dogs in agricultural and residential settings. Treatment: vitamin K1 for 2–4 weeks; prognosis good with early treatment. Outdoor burrowing pest applications (prairie dog, vole) in agricultural areas create exposure risks for working dogs and farm dogs that may encounter bait stations or poisoned animals.

What products contain chlorophacinone?

Chlorophacinone appears in: Manufacturing plants (Industrial facilities); Chemical storage areas (Industrial facilities); Factories (Occupational environments); Warehouses (Occupational environments).

See Chlorophacinone in the pets app

Look up products containing chlorophacinone, compare to alternatives, and explore the full data record.

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Sources (2)
  1. US EPA: Rodenticide Cluster Registration Review — diphacinone, chlorophacinone, warfarin (FGARs); brodifacoum, bromadiolone, difethialone, difenacoum (SGARs); bromethalin; cholecalciferol; zinc phosphide; risk assessment; use restrictions; Hawaii native bird program (2020) (2020) — regulatory
  2. ASPCA Animal Poison Control Center: Rodenticide Toxicosis in Dogs and Cats — anticoagulant SGARs/FGARs; bromethalin; cholecalciferol; zinc phosphide; vitamin K1 dosing; decontamination windows; INR monitoring; prognosis by rodenticide class (2023) (2023) — veterinary

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →