Pet Safety / Compounds / Bromadiolone

Is Bromadiolone safe for dogs and cats?

Extreme risk for pets

Bromadiolone is one of the most commonly implicated rodenticides in dog poisoning cases in the US and Europe — widely available in consumer bait stations and block formulations. Dogs access bait through direct station chewing or scavenging of poisoned rodents. Clinical coagulopathy appears 3–7 days post-ingestion; hemorrhagic signs are the same as brodifacoum (subcutaneous bleeding, epistaxis, hemothorax, hemoabdomen, sudden collapse). Treatment: vitamin K1 orally for 4–6 weeks; duration must be complete. Unlike brodifacoum, bromadiolone has a somewhat shorter environmental half-life (~80 days in dogs), but treatment duration is the same in practice because VKOR inhibition duration is determined empirically by INR normalization.

What is bromadiolone?

The IUPAC name is 3-[3-[4-(4-bromophenyl)phenyl]-3-hydroxy-1-phenylpropyl]-4-hydroxychromen-2-one.

Also known as: 3-[3-[4-(4-bromophenyl)phenyl]-3-hydroxy-1-phenylpropyl]-4-hydroxychromen-2-one, Broprodifacoum, Bromatrol, Super-rozol.

IUPAC name
3-[3-[4-(4-bromophenyl)phenyl]-3-hydroxy-1-phenylpropyl]-4-hydroxychromen-2-one
CAS number
28772-56-7
Molecular formula
C30H23BrO4
Molecular weight
527.4 g/mol
SMILES
C1=CC=C(C=C1)C(CC(C2=CC=C(C=C2)C3=CC=C(C=C3)Br)O)C4=C(C5=CC=CC=C5OC4=O)O
PubChem CID
54680085

Risk for dogs

Extreme risk

Bromadiolone is one of the most commonly implicated rodenticides in dog poisoning cases in the US and Europe — widely available in consumer bait stations and block formulations. Dogs access bait through direct station chewing or scavenging of poisoned rodents. Clinical coagulopathy appears 3–7 days post-ingestion; hemorrhagic signs are the same as brodifacoum (subcutaneous bleeding, epistaxis, hemothorax, hemoabdomen, sudden collapse). Treatment: vitamin K1 orally for 4–6 weeks; duration must be complete. Unlike brodifacoum, bromadiolone has a somewhat shorter environmental half-life (~80 days in dogs), but treatment duration is the same in practice because VKOR inhibition duration is determined empirically by INR normalization.

Risk for cats

Extreme risk

Cats are at risk from bromadiolone through secondary relay toxicosis (eating poisoned rodents) and direct bait access. Pleural hemorrhage (hemothorax) and subcutaneous bleeding are common presentations. Treatment: vitamin K1 for 4–6 weeks; minimize injections to reduce hematoma risk.

Regulatory consensus

1 regulatory bodyhas classified Bromadiolone.

AgencyYearClassificationNotes
Unknown——

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter bromadiolone

  • Industrial Facilities — Manufacturing plants, Chemical storage areas, Waste treatment sites
  • Occupational Environments — Factories, Warehouses, Transportation vehicles

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Bromadiolone:

  • Integrated Pest Management (IPM); Biopesticides; Physical controls
    Trade-offs: Combines biological, cultural, and targeted chemical controls; reduces overall chemical use 30-70%; requires trained practitioners and monitoring infrastructure; higher management complexity; proven effective at scale in many crop systems.
    Relative cost: 1.2-2×

Frequently asked questions

Is bromadiolone safe for pets?

Bromadiolone is one of the most commonly implicated rodenticides in dog poisoning cases in the US and Europe — widely available in consumer bait stations and block formulations. Dogs access bait through direct station chewing or scavenging of poisoned rodents. Clinical coagulopathy appears 3–7 days post-ingestion; hemorrhagic signs are the same as brodifacoum (subcutaneous bleeding, epistaxis, hemothorax, hemoabdomen, sudden collapse). Treatment: vitamin K1 orally for 4–6 weeks; duration must be complete. Unlike brodifacoum, bromadiolone has a somewhat shorter environmental half-life (~80 days in dogs), but treatment duration is the same in practice because VKOR inhibition duration is determined empirically by INR normalization.

What products contain bromadiolone?

Bromadiolone appears in: Manufacturing plants (Industrial facilities); Chemical storage areas (Industrial facilities); Factories (Occupational environments); Warehouses (Occupational environments).

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Sources (2)
  1. US EPA: Second-Generation Anticoagulant Rodenticides (SGARs) — Risk Mitigation Decision; brodifacoum, bromadiolone, difethialone, difenacoum; non-target wildlife secondary poisoning; restriction to certified pest control operators; tamper-resistant bait stations; consumer product phase-out (2011) (2011) — regulatory
  2. ASPCA Animal Poison Control Center: Rodenticide Toxicosis in Dogs and Cats — anticoagulant SGARs/FGARs; bromethalin; cholecalciferol; zinc phosphide; vitamin K1 dosing; decontamination windows; INR monitoring; prognosis by rodenticide class (2023) (2023) — veterinary

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →