Pet Safety / Compounds / Amprolium

Is Amprolium safe for dogs and cats?

Low risk for pets

Not veterinary or professional safety advice, and not a substitute for a veterinarian — consult one about your animal. Full disclaimer →

Used off-label for coccidiosis. Well-tolerated.

What is amprolium?

The IUPAC name is 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine chloride.

Also known as: Amprolio, 71M75T660B, 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride, 2-Picolinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-, chloride.

IUPAC name
5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine chloride
CAS number
121-25-5
Molecular formula
C14H19ClN4OS
Molecular weight
278.78 g/mol
SMILES
CCCC1=NC=C(C(=N1)N)C[N+]2=CC=CC=C2C.[Cl-]
PubChem CID
73341

Risk for dogs

Low risk

Used off-label for coccidiosis. Well-tolerated.

Risk for cats

Low risk

Used for feline coccidiosis. Similar safety.

Regulatory consensus

1 regulatory bodyhas classified Amprolium.

AgencyYearClassificationNotes
FDA1960Approved veterinary drug (NADA 048-083)

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter amprolium

  • Veterinary Medicine

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Amprolium:

  • Toltrazuril
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×
  • Diclazuril
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×

Frequently asked questions

Is amprolium safe for pets?

Used off-label for coccidiosis. Well-tolerated.

See Amprolium in the pets app

Look up products containing amprolium, compare to alternatives, and explore the full data record.

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Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →