Pet Safety / Compounds / Amprolium

Is Amprolium safe for dogs and cats?

Low risk for pets

Used off-label for coccidiosis. Well-tolerated.

What is amprolium?

CAS number
121-25-5
Molecular formula
C14H19ClN4OS
Molecular weight
278.78 g/mol
SMILES
CCC1=C(C=C(C=[N+]1CC2=CN=C(N=C2N)N)C)CN.[Cl-]
PubChem CID
8146

Risk for dogs

Low risk

Used off-label for coccidiosis. Well-tolerated.

Risk for cats

Low risk

Used for feline coccidiosis. Similar safety.

Regulatory consensus

1 regulatory bodyhas classified Amprolium.

AgencyYearClassificationNotes
FDA1960Approved veterinary drug (NADA 048-083)

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter amprolium

  • Veterinary Medicine

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Amprolium:

  • Toltrazuril
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×
  • Diclazuril
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×

Frequently asked questions

Is amprolium safe for pets?

Used off-label for coccidiosis. Well-tolerated.

See Amprolium in the pets app

Look up products containing amprolium, compare to alternatives, and explore the full data record.

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Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →