Pet Safety / Compounds / ADONA (4,8-dioxa-3H-perfluorononanoic acid)

Is ADONA (4,8-dioxa-3H-perfluorononanoic acid) safe for dogs and cats?

Moderate risk for pets

Not veterinary or professional safety advice, and not a substitute for a veterinarian — consult one about your animal. Full disclaimer →

Limited veterinary data. Expected shorter biological half-life than legacy PFAS.

What is adona (4,8-dioxa-3h-perfluorononanoic acid)?

The IUPAC name is 2,2,3-trifluoro-3-[1,1,2,2,3,3-hexafluoro-3-(trifluoromethoxy)propoxy]propanoic acid.

Also known as: RefChem:80841, Adona, 919005-14-4, 4,8-Dioxa-3H-perfluorononanoic acid.

IUPAC name
2,2,3-trifluoro-3-[1,1,2,2,3,3-hexafluoro-3-(trifluoromethoxy)propoxy]propanoic acid
CAS number
919005-14-4
Molecular formula
C7H2F12O4
Molecular weight
378.07 g/mol
SMILES
C(C(C(=O)O)(F)F)(OC(C(C(OC(F)(F)F)(F)F)(F)F)(F)F)F
PubChem CID
52915299

Risk for dogs

Moderate risk

Limited veterinary data. Expected shorter biological half-life than legacy PFAS.

Risk for cats

Moderate risk

No species-specific data available.

Regulatory consensus

2 regulatory and scientific bodies have classified ADONA (4,8-dioxa-3H-perfluorononanoic acid). The classifications differ — that's the data.

AgencyYearClassificationNotes
German UBA—Drinking water guidelineguideline value — German Federal Environment Agency set precautionary guideline of 10 μg/L
ECHA—PFAS restriction proposalproposed restriction

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter adona (4,8-dioxa-3h-perfluorononanoic acid)

  • Drinking Water — Alz River downstream of Dyneon/3M Gendorf plant (Germany), Groundwater near fluoropolymer manufacturing
    Detected at ng/L levels in German drinking water
  • Industrial Process — Fluoropolymer (PTFE, PFA) manufacturing as processing aid
    Used as emulsifier in fluoropolymer production since ~2008

Safer alternatives

Lower-risk approaches that achieve a similar outcome to ADONA (4,8-dioxa-3H-perfluorononanoic acid):

  • Non-fluorinated dispersions for fluoropolymer manufacture
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×
  • Aqueous polymerization without fluorosurfactants
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 0.8-1.5×

Frequently asked questions

Is adona (4,8-dioxa-3h-perfluorononanoic acid) safe for pets?

Limited veterinary data. Expected shorter biological half-life than legacy PFAS.

What products contain adona (4,8-dioxa-3h-perfluorononanoic acid)?

ADONA (4,8-dioxa-3H-perfluorononanoic acid) appears in: Alz River downstream of Dyneon/3M Gendorf plant (Germany) (drinking water); Groundwater near fluoropolymer manufacturing (drinking water); Fluoropolymer (PTFE, PFA) manufacturing as processing aid (industrial process).

Why do regulators disagree about adona (4,8-dioxa-3h-perfluorononanoic acid)?

ADONA (4,8-dioxa-3H-perfluorononanoic acid) has been classified by 2 agencies including German UBA, ECHA, with differing conclusions. Regulators apply different standards of evidence (animal data weighting, exposure-pattern assumptions, epidemiological power thresholds), which is why two scientific bodies can review the same data and reach different conclusions. See the regulatory consensus table on this page for the full picture.

See ADONA (4,8-dioxa-3H-perfluorononanoic acid) in the pets app

Look up products containing adona (4,8-dioxa-3h-perfluorononanoic acid), compare to alternatives, and explore the full data record.

Open in pets View raw API data

Sources (3)
  1. — expert_curation
  2. Fluorinated alternatives to long-chain PFAS: ADONA, GenX, F-53B (review) (2013) — review
  3. ECHA REACH dossier evaluation of ADONA (2020) — regulatory

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →