Pet Safety / Compounds / ADONA (4,8-dioxa-3H-perfluorononanoic acid)

Is ADONA (4,8-dioxa-3H-perfluorononanoic acid) safe for dogs and cats?

Moderate risk for pets

Limited veterinary data. Expected shorter biological half-life than legacy PFAS.

What is adona (4,8-dioxa-3h-perfluorononanoic acid)?

The IUPAC name is 2,2,3-trifluoro-3-[1,1,2,2,3,3-hexafluoro-3-(trifluoromethoxy)propoxy]propanoic acid.

Also known as: RefChem:80841, Adona, 919005-14-4, 4,8-Dioxa-3H-perfluorononanoic acid.

IUPAC name
2,2,3-trifluoro-3-[1,1,2,2,3,3-hexafluoro-3-(trifluoromethoxy)propoxy]propanoic acid
CAS number
919005-14-4
Molecular formula
C7H2F12O4
Molecular weight
378.07 g/mol
SMILES
C(C(C(=O)O)(F)F)(OC(C(C(OC(F)(F)F)(F)F)(F)F)(F)F)F
PubChem CID
52915299

Risk for dogs

Moderate risk

Limited veterinary data. Expected shorter biological half-life than legacy PFAS.

Risk for cats

Moderate risk

No species-specific data available.

Regulatory consensus

2 regulatory and scientific bodies have classified ADONA (4,8-dioxa-3H-perfluorononanoic acid). The classifications differ — that's the data.

AgencyYearClassificationNotes
German UBA——German Federal Environment Agency set precautionary guideline of 10 μg/L
ECHA——

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter adona (4,8-dioxa-3h-perfluorononanoic acid)

  • Drinking Water — Alz River downstream of Dyneon/3M Gendorf plant (Germany), Groundwater near fluoropolymer manufacturing
    Detected at ng/L levels in German drinking water
  • Industrial Process — Fluoropolymer (PTFE, PFA) manufacturing as processing aid
    Used as emulsifier in fluoropolymer production since ~2008

Safer alternatives

Lower-risk approaches that achieve a similar outcome to ADONA (4,8-dioxa-3H-perfluorononanoic acid):

  • Non-fluorinated dispersions for fluoropolymer manufacture
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×
  • Aqueous polymerization without fluorosurfactants
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 0.8-1.5×

Frequently asked questions

Is adona (4,8-dioxa-3h-perfluorononanoic acid) safe for pets?

Limited veterinary data. Expected shorter biological half-life than legacy PFAS.

What products contain adona (4,8-dioxa-3h-perfluorononanoic acid)?

ADONA (4,8-dioxa-3H-perfluorononanoic acid) appears in: Alz River downstream of Dyneon/3M Gendorf plant (Germany) (drinking water); Groundwater near fluoropolymer manufacturing (drinking water); Fluoropolymer (PTFE, PFA) manufacturing as processing aid (industrial process).

See ADONA (4,8-dioxa-3H-perfluorononanoic acid) in the pets app

Look up products containing adona (4,8-dioxa-3h-perfluorononanoic acid), compare to alternatives, and explore the full data record.

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Sources (1)
  1. — expert_curation

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →