Pet Safety / Compounds / 2C-B (4-Bromo-2,5-dimethoxyphenethylamine)

Is 2C-B (4-Bromo-2,5-dimethoxyphenethylamine) safe for dogs and cats?

Very high risk for cats · High risk for dogs

Not veterinary or professional safety advice, and not a substitute for a veterinarian — consult one about your animal. Full disclaimer →

Phenethylamine sensitivity. Any exposure requires immediate veterinary care.

What is 2c-b (4-bromo-2,5-dimethoxyphenethylamine)?

The IUPAC name is 2-(4-bromo-2,5-dimethoxyphenyl)ethanamine.

Also known as: 4-Bromo-2,5-dimethoxyphenethylamine, 66142-81-2, 2-(4-Bromo-2,5-dimethoxyphenyl)ethylamine, 2,5-Dimethoxy-4-bromophenethylamine.

IUPAC name
2-(4-bromo-2,5-dimethoxyphenyl)ethanamine
CAS number
66142-81-2
Molecular formula
C10H14BrNO2
Molecular weight
260.13 g/mol
SMILES
COc1cc(CCN)c(OC)cc1Br
PubChem CID
98527

Risk for dogs

High risk

Hallucinogenic phenethylamines cause disorientation, hyperthermia, seizures in dogs.

Risk for cats

Very high risk

Phenethylamine sensitivity. Any exposure requires immediate veterinary care.

Regulatory consensus

2 regulatory and scientific bodies have classified 2C-B (4-Bromo-2,5-dimethoxyphenethylamine). The classifications differ — that's the data.

AgencyYearClassificationNotes
DEA1995Schedule I controlled substance
UN20011971 Convention — Schedule II

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where pets encounter 2c-b (4-bromo-2,5-dimethoxyphenethylamine)

  • Illicit Drug
  • Research Chemical

Safer alternatives

Lower-risk approaches that achieve a similar outcome to 2C-B (4-Bromo-2,5-dimethoxyphenethylamine):

  • Psilocybin (in clinical/research context)
    Trade-offs: Better-characterized safety profile. Longer history of use. Still Schedule I but FDA Breakthrough Therapy.
    Relative cost: N/A (not legally available)

Frequently asked questions

Is 2c-b (4-bromo-2,5-dimethoxyphenethylamine) safe for pets?

Phenethylamine sensitivity. Any exposure requires immediate veterinary care.

Why do regulators disagree about 2c-b (4-bromo-2,5-dimethoxyphenethylamine)?

2C-B (4-Bromo-2,5-dimethoxyphenethylamine) has been classified by 2 agencies including DEA, UN, with differing conclusions. Regulators apply different standards of evidence (animal data weighting, exposure-pattern assumptions, epidemiological power thresholds), which is why two scientific bodies can review the same data and reach different conclusions. See the regulatory consensus table on this page for the full picture.

See 2C-B (4-Bromo-2,5-dimethoxyphenethylamine) in the pets app

Look up products containing 2c-b (4-bromo-2,5-dimethoxyphenethylamine), compare to alternatives, and explore the full data record.

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Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →